In vitro testing of the skin sensitizing potency of ingredients from epoxy resin systems with focus on the testing of so-called prepolymers

Project No. FF-FP 0451

Status:

ongoing

Aims:

This project aims at extending the scientific basis for the evaluation of the skin sensitizing potency of ingredients in epoxy resin systems by results of in vitro tests of the latest generation. The project aims to fill particularly important data gaps in the evaluation of the sensitizing potency of prepolymers. These are considered (with currently insufficient data available) to be promising ingredients of epoxy resin systems for the reduction of allergy potency. Furthermore, it is of particular importance to check whether the test results allow transfers (generalisable statements on the potency).

The test results obtained and the general rules derived from them are to be converted into corresponding practice-oriented decision-making aids for substance selection/substitution (e.g. substance lists with information on sensitizing potency).

Activities/Methods:

Taking into account the industrial application relevance, the state of the art of epoxy resin systems and from the substances that have not yet been categorised according to their sensitising potency, a corresponding substance list was generated in the run-up to the project. The test materials will be synthesized by representatives of the manufacturing industry and made available for testing free of charge. FoBiG is responsible for the coordination of the test material shipment. The substances are tested in the Genomic Allergen Rapid Detection (GARD™), an in vitro test for predicting the sensitizing properties and potency of chemicals. The turnaround time after receipt of the test materials is approximately 20 weeks. At the end of the testing and final discussion, a scientific report with the results of the tests performed will be available. These will be integrated by FoBiG into the final report of the present project.

Last Update:

08-May-2020

Project

Financed by:
  • Deutsche Gesetzliche Unfallversicherung e. V. (DGUV)
Research institution(s):
  • Forschungs- und Beratungsinstitut Gefahrstoffe GmbH (FoBiG)
Branche(s):

-cross sectoral-

Type of hazard:

dangerous substances

Catchwords:

chemical working substances, allergenic substances

Description, key words:

skin sensitizing , epoxy resin, in vitro tests