Analysis of human Polychlorinated biphenyls(PCB)-metabolism in order to predict individual risk to disease

Status:

ongoing

Aims:

The aim is to identify cytochrome P450 enzymes that contribute to the formation of reactive Hydroxy-PCB (OH-PCB) metabolites from selected PCB congeners and thus reveal a mechanically useful role in mediating the harmful effects of PCBs on human health.

Activities/Methods:

The research project is divided into two work packages. The overall goal, the analysis of cytochrome P450 enzymes and their involvement in PCB biotransformation, is divided into a discovery phase and a validation phase.

Work-Package 1: Genetic screen of cytochrome P450 enzymes and their function in PCB-Biotransformation of Drosophila melanogaster.

Work-Package 2: Cytochrome P450 isoenzyme dependent biotransformation of PCBs in human Jurkat-T cells and the resulting toxicity.

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