The aim is to identify cytochrome P450 enzymes that contribute to the formation of reactive Hydroxy-PCB (OH-PCB) metabolites from selected PCB congeners and thus reveal a mechanically useful role in mediating the harmful effects of PCBs on human health.
The research project is divided into two work packages. The overall goal, the analysis of cytochrome P450 enzymes and their involvement in PCB biotransformation, is divided into a discovery phase and a validation phase.
Work-Package 1: Genetic screen of cytochrome P450 enzymes and their function in PCB-Biotransformation of Drosophila melanogaster.
Work-Package 2: Cytochrome P450 isoenzyme dependent biotransformation of PCBs in human Jurkat-T cells and the resulting toxicity.
-cross sectoral-Type of hazard:
work-related diseases, dangerous substancesCatchwords:
occupational disease, carcinogenic substances, chemical working substancesDescription, key words: