Establishing ZIEL: ZNS - An interdisciplinary traumatic brain injury database for enhancing the evidence level of medical guidelines

Project No. FF-FR 0228




The project aims to improve the available evidence with regards to prognosis and therapy of traumatic brain injury (TBI) in multiple fields. Relevant confounders, such as disease modifying factors (DMFs) are suspected to worsen the outcome after TBI. However, DMFs have not been implemented in interdisciplinary guidelines for the treatment of TBI.

The ZIEL-database will represent a synchronization and extension of existing institutions. The Network to be established and extended consists of the European study CENTER-TBI (Collaborative European NeuroTrauma Effectiveness Research in TBI) and the Trauma Register DGU® that is prevailingly active in Germany. This new study-group of sufficient size will enable a reassessment of currently available but inconsistently applied therapeutic algorithms, relevant for clinical guidelines. In addition, the study will provide the basis for the development of new therapeutic strategies. Moreover, the ZIEL-database will serve for comparative investigation of clinically relevant DMFs after TBI, which are targets for prevention and treatment. Likewise, the quality of TBI specific care can be evaluated in an national as well as international context.


  • Generation of a TBI add-on module associated to the Trauma Register DGU® and compatible with the CENTER-TBI.
  • Extension of the TBI add-on module addressing DMFs.
  • Extraction and interim-analysis of datasets of the German CENTER-TBI participants and the Trauma Register DGU®.
  • Planning and development of a CENTER-TBI independent database, which can be continued -if applicable- after the end of recruitment into the CENTER-TBI study.
  • Planning of annual study meetings.

Last Update:



Financed by:
  • Deutsche Gesetzliche Unfallversicherung e. V. (DGUV)
Research institution(s):
  • Charité-Universitätsmedizin Berlin

-cross sectoral-

Type of hazard:




Description, key words:

ZNS, traumatic brain injury