Analytical study on testicular tumors occurring in automobile industry employees - embedded case-control-study

Project No. FF-FB 0087


completed 10/2008


The study of male germ cell cancer was designed to investigate an increased germ-cell tumor incidence among employees in the car-manufacturing industry.


To identify potential occupational and non-occupational risk factors, a case-control study including 205 germ-cell tumor patients and 1091 control persons employed in the automobile industry was conducted. Data were collected via personal interviews. For a subgroup of study subjects blood and urine samples were sampled for the purpose of a biological monitoring.


Summary of results:
1. The study did not indicate an increased germ-cell tumor risk due to occupational electromagnetic fields.
2. The increase in incidence cannot be explained by former or simultaneous activities in agriculture.
3. Slightly increased risks were implied for metal workers, particularly those involved in metal-cutting. It is possible that the observed associations may be explained by specific exposures to hazardous occupational substances. However, these associations have to be interpreted with caution and need to be verified in detail in subsequent analyses.
4. A possible risk increase was also implied for occupational handling of various hazardous substances such as bisphenol A, epoxy resins, the glycol ether EGBE, and dimethylformamide. Also, further research is warranted to verify the observed associations.

Last Update:



Financed by:
  • Deutsche Gesetzliche Unfallversicherung e. V. (DGUV)
Research institution(s):
  • Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung - Institut der Ruhr-Universität Bochum (IPA)
  • Bremer Institut für Präventionsforschung und Sozialmedizin BIPS

vehicle construction

Type of hazard:

Arbeitsbedingte Erkrankungen, Gefahrstoffe


Berufskrankheit, Krebserregende Stoffe, Exposition

Description, key words:

testicular tumors, automobile production, Cause study, increased rate of new disease cases, case-control study, cohort, automobile workers