Hazardous substance information system of the German Social Accident Insurance

Scheme: Derivation of DNELs

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Scheme: Derivation of DNELs


For the registration of each substance under the European chemicals regulation REACH, manufacturers or importers have to quote assessment benchmarks on which the protective measures are based. Among these assessment yardsticks are Derived No-Effect Levels (DNELs). The REACH regulation defines them as exposure levels beneath which a substance does not harm human health.

The GESTIS DNEL list of the German Social Accident Insurance (DGUV) is based on a compilation conducted by the social accident insurance institution for the construction industry which makes available workplace-related DNELs that have been established by manufacturers and importers on their own responsibility and are published in this form by the European Chemicals Agency (ECHA).

The DGUV GESTIS DNEL list currently contains DNELs for workers (local and/or systemic effects during long-term inhalation exposure) for roughly 6,000 substances. If different DNELs are published for a single substance, they are presented side-by-side. Carcinogens are specially marked. If there is also a workplace limit value that is binding in Germany, this is indicated. A link is provided to further substance-specific data in the GESTIS substance database if any.

This provides users with an overview of the DNELs published to date for long-term inhalative workplace exposure. These values can be referred to for the purpose of risk assessment of tasks involving hazardous substances, for example for the specification of protective measures and for review of their efficacy.

Further remarks:

Detailed information on the DNELs

Explanations on the GESTIS DNEL list


The GESTIS DNEL List has been produced and is maintained by the Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA) in conjunction with the German Social Accident Insurance Institutions and the representatives of the German regional governments, the Federal Institute for Occupational Safety and Health (BAuA), the association of the German chemical industry (VCI) and the Austrian General Accident Insurance Board (AUVA).

Use and Liability

The body of data is made available for the purpose of occupational safety and health. Commercial use of the data and their incorporation in full or in part into other information systems is not permitted. The data may be quoted on a limited scale with statement of the "GESTIS DNEL List" as the source. Care has been taken in preparation and maintenance of the data contained in the GESTIS DNEL List. No liability can however be assumed for these data on whatever legal basis.

Further reading

Tynkkynen, S.; Santonen, T.; Stockmann-Juvala, H.: A Comparison of REACH-Derived No-Effect Levels for Workers with EU Indicative Occupational Exposure Limit Values and National Limit Values in Finland. Ann Occup Hyg 59 (2015) No. 4, pp. 401-415

Schenk, L.; Deng, U.; Johanson, G.: Derived No-effect Levels (DNELs) under the European Chemicals Regulation REACH – An Analysis of Long-term Inhalation Worker-DNELs Presented by Industry. Ann Occup Hyg 59 (2015) No. 4, pp. 416-438

Schenk, L.; Palmen, N.; Theodori, D.: Evaluation of worker inhalation DNELs. Part A: Quality assessment of a selection of DNELs. Part B: Discussion paper on the possibilities to improve the overall quality of DN(M)ELs. RIVM Letter report 110001001/2014. National Institute for Public Health and the Environment, Bilthoven/The Netherlands 2014

Hammerschmidt, T.; Marx, R.: REACH and occupational health and safety. Environmental Sciences Europe 26 (2014) No. 6

Scheffers, T.; Wieling, G.: Careful with that DNEL, Occupational Hygienist! (PDF, 1.4 MB, non-accessible) BOHS Exposure Magazine 3 (2014) No. 6, pp. 39-40

Nies, E.; Musanke, U.; Püringer, J.; Rühl, R.; Arnone, M.: DNELs for workplaces – observations from an inspection of the DGUV DNEL list (PDF, 419 kB, non-accessible) . Gefahrstoffe - Reinhaltung der Luft 73 (2013) No. 11/12, pp. 455-462

Further publications (in German)

Further information

  • Risk assessments for activities involving hazardous substances (TRGS 400)
  • Identification and assessment of the risks from activities involving hazardous substances: inhalation exposure (TRGS 402)


Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA)
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Dr Susanne Zöllner
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