TRGS 905 categorises man made mineral fibres (MMMF) of certain proportions and material composition as carcinogenic in category 2 or 3 in accordance with the dangerous chemicals regulation. Bio-degradability is a further categorisation criterion without, however, providing concrete indication of limit values for differentiation between categories, because the methods to determine bio-degradability are insufficiently standardised and there is no certain correlation between bio-degradability and carcinogenic effect. Goal: elaboration of a standard measuring procedure as well as evaluation of criteria concerning carcinogenic effects for the persistence of man made mineral fibres in the organism
Examination of 7 fibre materials (2 additional ones in BAuA-Project F1249); parallel investigations with identical fibre samples under inhalation, intratracheal instillation, intraperitoneal injection and in-vitro to determine in-vivo persistence, in-vitro solubility and carcinogenic potential; elaboration of framework conditions for standardised tests; validation of in-vitro method
Correlation between in-vivo decay time (rat lungs) and in-vitro solubility speed; intratracheal instillation as well as short-period inhalation put experimental limits to the evidence of the results. For important fibres (large production quantities, unavoidable exposure when used) both procedures should be applied and, where insufficient correlation exists, be supplemented by subchronic inhalation test with recovery period (EPA 1995). Toxicological and occupational medical assessment of mineral fibres requires a correlation between bio-persistent decay times and carcinogenic effect (further research).
Muhle, H. u.a.: Fasern-Tests zur Abschätzung der Biobeständigkeit und zum Verstaubungsverhalten. BIA-Report 2/98. Hrsg.: Hauptverband der gewerblichen Berufsgenossenschaften (HVBG), Sankt Augustin 1998
-cross sectoral-Type of hazard:
Gefährdungsbeurteilung, krebserregende Stoffe, ToxikologieDescription, key words:
Indications regarding the application of methods to determine the bio-persistence of man made mineral fibres and evaluation of the results