There are different approaches how a systemic activation of the innate immune system after severe burns could take place. In this context, both human host defense peptides (hHDPs), as part of the innate immune response, as well as microRNAs (miRNAs) play a decisive role. While the importance of miRNAs is currently the subject of various research projects, the role of exosomes in the systemic activation of the congenital immune system is largely unknown.
The aim of this study is to characterize the immune responses and systemic kinetics of effector molecules (hHDPs), exosomes and microRNAs after burn injuries and sepsis thus to obtain possible markers for the severity of the injury, the development and course of sepsis.
We hope that the combination of the chosen targets and the methods of investigation will allow us to establish a clear relationship between the parameters and thus also to achieve a separation between the initial trauma and time related changes that are occurring.
-cross sectoral-Type of hazard:
rehabilitationDescription, key words:
kinetics, effector molecules, burn injuries, sepsis