This research project aims to investigate whether people suffering from allergies/sensitization show a generally increased susceptibility in the context of exposures to local irritants. Since contradictory results on this topic have been published, there are some uncertainties if this "susceptibility" needs to be considered in the context of the regulation of local irritants by health-based occupational exposure limits. The main goal of our research is to broaden the empirical evidence for this topic by generating additional and reliable human data. Thereby, the decision about the necessity of using an intraspecies extrapolation factor in the context of local effects in humans can be scientifically supported.
The funded research module is based on the technique of experimental exposure of human volunteers of both sexes. In half of the participants allergies/sensitizations have been confirmed by a physician and by testing allergen-specific IgEs. The other half of the total sample consists of healthy controls. Outside the pollen season all participants will be exposed to two different concentrations of an irritant (in the range of the MAK-value and the odor threshold) in the exposure laboratory at the IfADo. By using the well-established multi-level approach combining perception, behavior and physiology when assessing the dependent variables (e.g. eye blink frequency) concentration and susceptibility dependent effects will be assessed.
-cross sectoral-Type of hazard:
prevention, information systemDescription, key words:
Irritative effects, chemosensory effects, sensitization, allergic rhinitis, local irritants, exposure