Validation of new biomarkers for early diagnosis of mesothelioma in a longitudinal study - sub-project vital status research -

Project No. FF-FB 0111

Status:

completed 11/2007

Aims:

During the "HRCT-Study" in the years 1993 to 1997 with 636 former asbestos exposed persons x-ray and CT examination, a physical examination, an anamnesis, a lung function scan were gathered for each patient. Partly blood samples were taken and stored at the BGFA - Research Institute of Occupational Medicine in Bochum. It is planned to use this highly documented cohort of former asbestos exposed persons to evaluate biomarkers that might lead to an early identification of mesothelioma. Within this partial project the current vital status of the back then examined persons was recorded.

Activities/Methods:

- current address research
- mail to local residents´ registration offices and retrieve vital status
- detect deceased persons
- request death declaration from public health department

Results:

Within a vital status inquiry the addresses of 636 persons were compiled with the corresponding local residents' registration offices. From the 137 deceased test persons the cause of death was compiled from the responsible public health departments. Within the mentioned cohort 12 lung cancer diseases and 20 mesothelioma diseases could be detected within the observation period. The results of the vital status update were given to the BGFA for further processing and joining with the biomarker analyses. We expect three publications from the main study. One is already published concerning methodical aspects.

Last Update:

06-Aug-2009

Project

Financed by:
  • Deutsche Gesetzliche Unfallversicherung e. V. (DGUV)
Research institution(s):
  • Institut für Arbeitsmedizin der RWTH Aachen
Branche(s):

-cross sectoral-

Type of hazard:

dangerous substances

Catchwords:

Berufskrankheit, Krebserregende Stoffe

Description, key words:

biomarker, mesotheliom, asbestos, HRCT-Study

Further information

Daniel G. Weber, Dirk Taeger, Beate Pesch, Thomas Kraus, Thomas Brüning, Georg Johnen: Soluble mesothelin-related peptides (SMRP) - High stability of a potential tumor marker for mesothelioma. Cancer Biomarkers 3 (2007) 1-6