Neurotoxicity of solvent mixtures

Project No. FFFF 0172

Status:

completed 07/2001

Aims:

Investigating acute effects of organic solvents is normally done on single solvents. In practice mixtures are used, causing possible interactions of the components.

Activities/Methods:

12 test subjects were exposed in an exposure chamber at controlled conditions; biological monitoring, neurophysiological (quantitative analysis of EEG) and psychological tests.

Results:

No additional effects of mixture-components; subclinical central nervous effects proven; significant reduction of vigilance from n-heptane exposition at 500 ppm (german threshold limit value MAK).

Publications:

Muttray, A.; Martus, P.; Schachtrup, S.; Müller, E.; Mayer-Popken, O.; Konietzko, J.: Acute exposure to a mixture containing toluene decreases a2-power in the human EEG. 8th international symposium on neurobehavioral methods and effects in occupational and environmental health. Brescia, 23.-26.06.2002, Congress Report

Muttray, A.; Martus, P.; Schachtrup, S.; Müller, E.; Mayer-Popken, O.; Konietzko, J.: Acute effects of an organic solvent mixture on the human central nervous system (PDF, 118 kB). Eur. J. Med. Res. (2005) No. 10, pp. 381-388

Last Update:

28-Nov-2002

Project

Financed by:
  • Hauptverband der gewerblichen Berufsgenossenschaften (HVBG)
Research institution(s):
  • Institut für Arbeitsmedizin, Universität Mainz
Branche(s):

-cross sectoral-

Type of hazard:

dangerous substances

Catchwords:

Lösungsmittel, Toxikologie, Grenzwert

Description, key words:

acute effects of mixtures of organic solvents on the human central nervous system