Early detection study for urinary bladder cancer in a risk collective - Subproject 2

Project No. FF-FB 0093

Status:

completed 12/2010

Aims:

Early detection study for urinary bladder cancer in a risk collective
- Early detection of bladder cancer in chemical workers formerly exposed to aromatic amines by means of established and newly developed molecular markers
- Identification of statistical parameters for the predictive value of the tumor markers investigated

Activities/Methods:

Prospective cohort study (Department of Urology, Tübingen; BASF AG, Ludwigshafen; BAYER AG, Leverkusen; Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin, Bochum; BG Chemie, Heidelberg)
- Investigation of risk factors
- Development of a job exposure matrix (JEM)
- Analyses for various urine bound tumor markers
- statistical tests for the accuracy of the tumor markers

Results:

The prospective study UroScree was conducted from September 2003 to June 2010. Overall 1609 persons, who were exposed to cancinogenic aromatic amines, were examined.Additionally to the established diagnostics with urine sediment and cytology (berufsgenossenschaftlicher G33) the marker NMP22® , Urovysion® as well as the experimental marker Survivin were determined.
The analyses confirm, that clinical side reports like inflammations oder haematuria are accompanied with higher values of protein based markers like NMP22. Analyses of the amount of creatinine showed, that with values of creatinine i.U. 2,5 g/l more positive reports were found.

Last Update:

03-Aug-2011

Project

Financed by:
  • Deutsche Gesetzliche Unfallversicherung e.V. (DGUV)
Research institution(s):
  • Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung - Institut der Ruhr-Universität Bochum (IPA)
  • Berufsgenossenschaft Rohstoffe und chemische Industrie (BG RCI)
  • Universitätsklinikum Tübingen (Forschungsleitung)
  • BASF SE, Occupational Medicine & Health Protection, Ludwigshafen
  • Currenta GmbH & Co.OHG (früher BAYER AG), Sicherheit-Gesundheitsschutz, Leverkusen
  • Organisationsdienst für nachgehende Untersuchungen (ODIN), Heidelberg
Branche(s):

chemical industry

Type of hazard:

dangerous substances

Catchwords:

Berufskrankheit, Krebserregende Stoffe, Epidemiologie

Description, key words:

aromatic amines, chemical worker, tumours markers, early detection, urinary bladder cancer

Further information

Project IPA27 (only in German)

Pesch B, Nasterlack M, Eberle F, Bonberg N, Taeger D, Leng G, Feil G, Johnen G, Ickstadt K, Kluckert M, Wellhäußer H, Stenzl A, Brüning T; the UroScreen Group: The role of haematuria in bladder cancer screening among men with former occupational exposure to aromatic amines. BJU Int. (doi:10.1111/j.1464-410X.2010.09971.x)

Nasterlack M, Feil G, Leng G, Pesch B, Huber S, Sievert K-D, Johnen G, Taeger D, Mayer T, Kluckert M, Brüning T, Stenzl A und die UroScreen-Studiengruppe: Das superfizielle Harnblasenkarzinomen und Screening mittels urinbasierter Tumormarker - Erfahrungen aus der Arbeitsmedizin. Aktuelle Urologie 2011