Implantable Microsystem for the Adaptation of the Spinal Cord after Paraplegia

Project-Nr. FF-FR0162

Status:

ongoing 08/2009

Aims:

The aim of the project is to enhance lately developed biochemical methods by a surgical procedure for the adaptation of the injured spinal cord structures towards an entire concept of the treatment after paraplegia.
The core of the plan is the development of a biocompatible microsystem ("chip") which allows directed growing of axons and a mechanical connection of the tissue structures as well as targeted drug delivery to the connection area.

Activities/Methods:

Based on microsystem technologies a connecting element is produced which consists of microstructures with numerous parallel tubes as well as additional transverse canals.
For this a moulding method for bioabsorbable materials has to be developed which permits an accurate moulding of the microstructures. The implants are tested in animal experiments on rats.
Histologic and behavioral investigations to proof the function of the system are planned. Other main focus of the project is the development of potential clinical application procedures together with the establishment of a valid surgical methodology.

Last update:

27/04/10